ip About Diprivan - DIPRIVAN® (Propofol) Injectable Emulsion, USP

Diprivan (Propofol) Injectable Emulsion, USP is the #1 prescribed propofol in the U.S.¹

Diprivan is the only propofol containing EDTA in the U.S.

EDTA (Disodium Edetate) is an antimicrobial retardant. This formulation of propofol with EDTA is exclusively available from Fresenius Kabi.

DIPRIVAN medication types

Diprivan product features

  • Contains EDTA (Disodium Edetate)
  • Sulfite free
  • Benzyl alcohol free
  • Container closures are not made with natural rubber latex
  • Bar coded
  • Spike-and-hang vial (50 mL and 100 mL)

Indications and Dosing

Summary of Dosage Guidelines: Dosages and rates of administration in the following table should be individualized and titrated to clinical response. Safety and dosing requirements for induction of anesthesia in pediatric patients have only been established for children 3 years of age or older. Safety and dosing requirements for the maintenance of anesthesia have only been established for children 2 months of age and older. (See DOSAGE AND ADMINISTRATION in Full Prescribing Information)

Induction of General Anesthesia

Patients ≥3 years of age

Healthy Adults Less Than 55 Years of Age:

40 mg every 10 seconds until induction onset (2 mg/kg to 2.5 mg/kg).

Elderly, Debilitated, or ASA-PS III or IV Patients:

20 mg every 10 seconds until induction onset (1 mg/kg to 1.5 mg/kg).

Cardiac Anesthesia:

20 mg every 10 seconds until induction onset (0.5 mg/kg to 1.5 mg/kg).

Neurosurgical Patients:

20 mg every 10 seconds until induction onset (1 mg/kg to 2 mg/kg).

Pediatric Patients—healthy, from 3 years to 16 years of age:

2.5 mg/kg to 3.5 mg/kg administered over 20 to 30 seconds.

(see PRECAUTIONS, Pediatric Use and CLINICAL PHARMACOLOGY, Pediatrics in Full Prescribing Information)

Maintenance of General Anesthesia—Infusion

Patients ≥2 months of age

Healthy Adults Less Than 55 Years of Age:

100 mcg/kg/min to 200 mcg/kg/min (6 mg/kg/h to 12 mg/kg/h).

Elderly, Debilitated, or ASA-PS III or IV Patients:

50 mcg/kg/min to 100 mcg/kg/min (3 mg/kg/h to 6 mg/kg/h).

Cardiac Anesthesia:

Most patients require:

Primary Diprivan Injectable Emulsion with Secondary Opioid—
100 mcg/kg/min to 150 mcg/kg/min

Low-Dose Diprivan Injectable Emulsion with Primary Opioid—
50 mcg/kg/min to 100 mcg/kg/min

(see DOSAGE AND ADMINISTRATION, Table 4 in Full Prescribing Information)

Neurosurgical Patients:

100 mcg/kg/min to 200 mcg/kg/min (6 mg/kg/h to 12 mg/kg/h).

Pediatric Patients—healthy, from 2 months of age to 16 years of age:

125 mcg/kg/min to 300 mcg/kg/min (7.5 mg/kg/h to 18 mg/kg/h).

Following the first half hour of maintenance, if clinical signs of light anesthesia are not present, the infusion rate should be decreased.

(see PRECAUTIONS, Pediatric Use and CLINICAL PHARMACOLOGY, Pediatrics in Full Prescribing Information)

Maintenance of General Anesthesia—Intermittent Bolus

Adults only

Healthy Adults Less Than 55 Years of Age:

Increments of 20 mg to 50 mg as needed.

Initiation of MAC Sedation

Adults only

Healthy Adults Less Than 55 Years of Age:

Slow infusion or slow injection techniques are recommended to avoid apnea or hypotension. Most patients require an infusion of 100 mcg/kg/min to 150 mcg/kg/min (6 mg/kg/h to 9 mg/kg/h) for 3 minutes to 5 minutes or a slow injection of 0.5 mg/kg over 3 minutes to 5 minutes followed immediately by a maintenance infusion.

Elderly, Debilitated, Neurosurgical, or ASA-PS III or IV Patients:

Most patients require dosages similar to healthy adults. Rapid boluses are to be avoided (see warnings in Full Prescribing Information)

Maintenance of MAC Sedation

Adults only

Healthy Adults Less Than 55 Years of Age:

A variable rate infusion technique is preferable over an intermittent bolus technique. Most patients require an infusion of 25 mcg/kg/min to 75 mcg/kg/min (1.5 mg/kg/h to 4.5 mg/kg/h) or incremental bolus doses of 10 mg or 20 mg.

Elderly, Debilitated, Neurosurgical, or ASA-PS III or IV Patients:

Most patients require 80% of the usual adult dose. A rapid (single or repeated) bolus dose should not be used (see warnings in Full Prescribing Information)

Initiation and Maintenance of ICU Sedation in Intubated,
Mechanically Ventilated Adult Patients

Because of the residual effects of previous anesthetic or sedative agents, in most patients the initial infusion should be 5 mcg/kg/min (0.3 mg/kg/h) for at least 5 minutes. Subsequent increments of 5 mcg/kg/min to 10 mcg/kg/min (0.3 mg/kg/h to 0.6 mg/kg/h) over 5 to 10 minutes may be used until desired clinical effect is achieved. Maintenance rates of 5 mcg/kg/min to 50 mcg/kg/min (0.3 mg/kg/h to 3 mg/kg/h) or higher may be required. Administration should not exceed 4 mg/kg/hour unless the benefits outweigh the risks (see WARNINGS in Full Prescribing Information)

Evaluation of clinical effect and assessment of CNS function should be carried out daily throughout maintenance to determine the minimum dose of Diprivan Injectable Emulsion required for sedation.

The tubing and any unused portions of Diprivan Injectable Emulsion should be discarded after 12 hours because Diprivan Injectable Emulsion contains no preservatives and is capable of supporting growth of microorganisms (see WARNINGS and DOSAGE AND ADMINISTRATION in Full Prescribing Information).

Combined Sedation and Regional Anesthesia

Adults only

See PRECAUTIONS in Full Prescribing Information

Reference
  1. Diprivan data on file.