How Fresenius Kabi makes sure DIPRIVAN is there for you
Fresenius Kabi leadership: our ongoing investments have enabled us to meet U.S. propofol demand with continuous supply during shortages.¹
From obtaining the raw materials to delivering DIPRIVAN to you, it can take as much as 6 months to produce a vial.
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We begin by sourcing components of the drug and the packaging materials, which include many things like: API (Active Pharmaceutical Ingredient), glass vials, stoppers, labels, shipping materials, and much more.
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Next comes production planning: making sure we have everything we need to meet demand for DIPRIVAN. We prepare for bulk production by assessing the ingredients using specific software.
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The emulsion is prepared by mixing, filtering, and homogenizing in a series of precise steps.
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Quality control monitors and inspects the vials at every step, where product- and process-specific parameters are analyzed.
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Vials are carefully filled, sealed, and crimped in a sterile, clean room.
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Product quality is analyzed by batch in a series of tests. If the batch is good, the process keeps moving.
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After inspection, the vials are labeled and packaged.
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In the final weeks, the vials are shipped and stored under temperature-controlled conditions.
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Many things can affect this process. For example, a shortage of materials or surge in demand. So we keep a 6-month inventory of raw materials on hand in our manufacturing facilities.
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We don't make DIPRIVAN in just one manufacturing facility. We have global production sites approved to produce DIPRIVAN. If there's a problem in one facility, another can pick up the shortfall.
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We also strive to keep 4 months' inventory of finished DIPRIVAN in our domestic warehouses so we're well ahead of demand.
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And our ongoing investments will continue to support your needs today and tomorrow. That's why Fresenius Kabi can confidently supply you with DIPRIVAN when you need it.
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Fresenius Kabi's response to the propofol drug shortages
When propofol suppliers contracted from 3 to only 1, and supply became critically low, Fresenius Kabi acted swiftly to help fill the void.
Today, Fresenius Kabi remains a reliable supplier and U.S. market leader with a global commitment to keep patient care running smoothly.